{
  "trial": {
    "name": "Bioavailability Crossover Study",
    "design": {
      "type": "crossover_2x2",
      "washout_duration": 7.0
    },
    "sequences": [
      {
        "name": "Sequence_AB",
        "n": 12,
        "treatments": ["Reference", "Test"]
      },
      {
        "name": "Sequence_BA",
        "n": 12,
        "treatments": ["Test", "Reference"]
      }
    ],
    "treatments": {
      "Reference": {"type": "single", "dose": 100.0},
      "Test": {"type": "single", "dose": 100.0}
    },
    "pk_sampling_times": [0, 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24],
    "endpoints": ["cmax", "auc_0_inf"],
    "seed": 42
  }
}