{
  "escalation_trial": {
    "name": "Phase I FIH Dose Escalation",
    "design": {
      "type": "3plus3",
      "dose_levels": [10.0, 25.0, 50.0, 100.0, 200.0],
      "starting_dose": 10.0,
      "max_dlt_rate": 0.33,
      "cohort_size": 3,
      "max_subjects": 30
    },
    "dlt_probabilities": {
      "10.0": 0.05,
      "25.0": 0.10,
      "50.0": 0.18,
      "100.0": 0.35,
      "200.0": 0.55
    },
    "regimen": {
      "frequency": "qd",
      "duration_days": 28
    },
    "seed": 42
  }
}