{
  "be_trial": {
    "name": "Generic Bioequivalence Study",
    "design": {
      "type": "bioequivalence",
      "n_periods": 2,
      "n_sequences": 2,
      "washout_duration": 7.0,
      "bioequivalence_limits": [0.80, 1.25],
      "parameters": ["cmax", "auc_0_inf"],
      "regulatory_guidance": "fda"
    },
    "n_per_sequence": 12,
    "treatments": {
      "Reference": {"type": "single", "dose": 100.0},
      "Test": {"type": "single", "dose": 100.0}
    },
    "pk_sampling_times": [0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24],
    "intra_subject_cv": 0.25,
    "seed": 42
  }
}