FOCE-I One-Compartment Estimation¶
Parameter estimation using FOCE-I method on simulated oral PK data.
Model¶
Structural:
Statistical:
CL_i = θ_CL × exp(η_CL,i)
V_i = θ_V × exp(η_V,i)
Ka_i = θ_Ka × exp(η_Ka,i)
Y_ij = F_ij × (1 + ε_ij) # Proportional error
Data¶
Simulated data for 30 subjects: - 100 mg oral dose at t=0 - Sampling at 0.5, 1, 2, 4, 6, 8, 12, 24h - True parameters: CL=5, V=50, Ka=1.5 - IIV: ω_CL=0.3, ω_V=0.2, ω_Ka=0.4
Files¶
| File | Description |
|---|---|
julia.jl |
Julia estimation |
python.py |
Python estimation |
data.csv |
Observed data |
expected_results.json |
Expected parameter estimates |