Population PKPD Analysis Use Case
Complete population pharmacokinetic-pharmacodynamic (PKPD) analysis workflow
demonstrating drug exposure-response modeling with indirect response dynamics.
Model Structure
PK Component
- Model: Two-compartment oral
- Parameters: Ka, CL, V1, Q, V2
- Covariates: Weight on CL and V1
PD Component
- Model: Indirect response (inhibition of production)
- Parameters: Kin, Kout, Imax, IC50
- Baseline: E0 = Kin/Kout
Workflow Steps
| Step |
Script |
Description |
| 1 |
run.jl |
Complete PKPD simulation and analysis |
Quick Run
# Run complete PKPD workflow
julia --project=packages/core docs/examples/use_cases/population_pkpd_analysis/run.jl
# Validate outputs
julia --project=packages/core docs/examples/use_cases/population_pkpd_analysis/validate.jl
Population
| Parameter |
Description |
| N |
50 subjects |
| Weight |
50-100 kg (uniform) |
| Dose |
50 mg oral |
| Sampling |
PK: 0-24h, PD: 0-72h |
Expected Results
PK Parameters (Population)
| Parameter |
Typical |
IIV (CV%) |
| Ka |
1.0 /h |
30 |
| CL |
5.0 L/h |
25 |
| V1 |
20 L |
20 |
| Q |
2.0 L/h |
- |
| V2 |
40 L |
- |
PD Parameters (Population)
| Parameter |
Typical |
IIV (CV%) |
| Kin |
1.0 /h |
20 |
| Kout |
0.1 /h |
20 |
| Imax |
0.9 |
15 |
| IC50 |
2.0 mg/L |
30 |
Key Findings
- Cmax (PK): ~5 mg/L
- E_max inhibition: ~45% from baseline
- Time to max PD effect: ~8-12 hours post-dose
- PD recovery: ~80% by 72 hours
See Also