Non-Compartmental Analysis (NCA)¶

Examples demonstrating NCA metrics computation from concentration-time data.

Computed Metrics¶

Metric	Description	Units
Cmax	Maximum concentration	mg/L
Tmax	Time of maximum concentration	h
AUC_0_t	AUC from 0 to last observation	mg·h/L
AUC_0_inf	AUC extrapolated to infinity	mg·h/L
t_half	Terminal half-life	h
CL_F	Apparent clearance	L/h
Vz_F	Apparent volume	L
MRT	Mean residence time	h

Examples¶

Example	Description	Directory
Basic NCA	Single subject NCA	01_basic_nca
Population NCA	Summary statistics	02_population_nca

Usage¶

using NeoPKPD

# Compute NCA metrics
result = compute_nca(
    times = [0, 0.5, 1, 2, 4, 8, 12, 24],
    concentrations = [2.0, 1.8, 1.5, 1.2, 0.8, 0.4, 0.2, 0.05],
    dose = 100.0,
    route = :iv
)

println("Cmax: $(result.cmax)")
println("AUC_0_inf: $(result.auc_0_inf)")
println("t_half: $(result.t_half)")

from neopkpd.nca import compute_nca

result = compute_nca(
    times=[0, 0.5, 1, 2, 4, 8, 12, 24],
    concentrations=[2.0, 1.8, 1.5, 1.2, 0.8, 0.4, 0.2, 0.05],
    dose=100.0,
    route="iv"
)