NONMEM ADVAN1 Import

Import a one-compartment IV bolus model from NONMEM control file.

NONMEM Model

• ADVAN: 1 (One-compartment)
• TRANS: 2 (CL, V parameterization)
• Parameters: CL=5.0 L/h, V=50.0 L
• IIV: CL (30% CV), V (25% CV)
• Error: Proportional (10% CV)

Files

File	Description
run001.ctl	NONMEM control file
convert.py	Python conversion
convert.jl	Julia conversion
expected.json	Expected NeoPKPD spec

Conversion

from neopkpd import import_nonmem

model = import_nonmem("run001.ctl")
print(model.spec)  # NeoPKPD ModelSpec

Parameter Mapping

NONMEM	NeoPKPD
THETA(1) = CL	params.CL
THETA(2) = V	params.V
OMEGA(1,1)	iiv.omegas.CL
OMEGA(2,2)	iiv.omegas.V
SIGMA(1,1)	error.proportional