NONMEM ADVAN2 Import

Import a one-compartment oral model with first-order absorption from NONMEM.

NONMEM Model

• ADVAN: 2 (One-compartment with first-order absorption)
• TRANS: 2 (CL, V, Ka parameterization)
• Parameters: Ka=1.5 1/h, CL=5.0 L/h, V=50.0 L
• IIV: Ka (40% CV), CL (30% CV), V (25% CV)
• Error: Combined (additive + proportional)

Files

File	Description
run002.ctl	NONMEM control file
convert.py	Python conversion
expected.json	Expected NeoPKPD spec

Parameter Mapping

NONMEM	NeoPKPD
THETA(1) = Ka	params.Ka
THETA(2) = CL	params.CL
THETA(3) = V	params.V
OMEGA(1,1)	iiv.omegas.Ka
OMEGA(2,2)	iiv.omegas.CL
OMEGA(3,3)	iiv.omegas.V