PKPD Biomarker Turnover¶
This use case models exposure-driven biomarker suppression using a coupled PKPD indirect response turnover model.
Purpose¶
- Validate coupled PKPD, regimen comparison, and IOV behavior under realistic workflows
- Provide a reproducible, replayable contract for response metrics used in decision making
Models¶
PK Model: One-compartment IV bolus (CL=10 L/h, V=50 L typical)
PD Model: Indirect response turnover - Baseline R0 = Kin / Kout = 100 - Drug effect: inhibitory Emax (Imax=0.9, IC50=5)
Scenarios¶
| Regimen | Doses |
|---|---|
| QD | 100 mg at 0, 24, 48 h |
| BID | 50 mg at 0, 12, 24, 36, 48, 60 h |
Each scenario runs with and without IOV on CL across occasions.
Outputs¶
- Population artifacts with mean and quantile response summaries
- Decision metrics: Emin, time below 80% baseline, suppression AUC