2x2 Crossover Design¶

Two-period, two-sequence crossover study for within-subject comparison.

Design¶

Type: 2x2 crossover (AB, BA)
Treatments: Reference vs Test formulation
Washout: 7 days between periods
N per sequence: 12 subjects
Endpoints: PK exposure (Cmax, AUC)

Sequences¶

Sequence	Period 1	Washout	Period 2
AB	Reference	7 days	Test
BA	Test	7 days	Reference

Features Demonstrated¶

2x2 crossover design creation
Washout period specification
Period-specific dosing
Within-subject analysis

Files¶

File	Description
python.py	Python implementation
julia.jl	Julia implementation
cli.json	CLI specification

Expected Output¶

2x2 Crossover Study
===================
Design: 2 periods, 2 sequences
Washout: 7 days

Sequence AB: 12 subjects
Sequence BA: 12 subjects

Completion rate: 95.8%